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Environmental Fate

River, Environment

We have state of the art analytical capability to perform the studies below using radiolabelled or non-radiolabelled test items, giving our customers more flexibility to their ERA approach.

As more parent associated metabolite fate studies are required, Fera offer a range of bespoke studies which meet regulatory requirements. We can tailor the design of the standard OECD studies to meet specific customer requirements. We amend the test matrix, design and analysis to suit the analyte in question giving our customers more options to their risk assessment.

Fera's expert team supports its customers during the entire regulatory process, from questions about compound formulation to regulator queries regarding submitted risk assessments.

Current OECD Fate and Behaviour studies within Veterinary Medicines performed at Fera

  • OECD 106 / 121 - Adsorption/Desorption Using a Batch Equilibrium Method
  • OECD 307 - Aerobic and Anaerobic Transformation in Soil
  • OECD 308 - Aerobic and Anaerobic Transformation in Aquatic Sediment Systems
  • OECD 309 – Aerobic Mineralisation in Surface Water - Simulation Biodegradation Test
  • OECD 316 - Phototransformation of Chemicals in Water- Direct Photolysis
  • EMA/CVMP 2011 - Fate of Veterinary Medicinal products in Manure / Slurry

Our laboratories

Our laboratories are equipped with state-of-the-art facilities that enable cost-effective performance of GLP compliant contract research environmental fate studies for pesticides, veterinary medicines, pharmaceuticals and industrial chemicals to satisfy regulatory requirements including:

  • Laboratory (GLP) analytical services for agrochemicals, REACH, veterinary medicinal products
  • Laboratory studies with radio-labelled and non-radiolabelled chemicals
  • Batch sorption including aged sorption and column leaching studies according to OECD guidelines and parameter estimation
  • Soil, water-sediment and manure/slurry biodegradation studies including estimation of degradation parameters and endpoints
  • Hard (man-made) surfaces fate studies including lab-scale sorption, wash-off, and field monitoring studies
  • Design, interpretation and analysis of lysimeter, field leaching, field dissipation and environmental (e.g. groundwater) monitoring studies

CCSS scientists have also undertaken bespoke studies investigating the fate of chemicals under non-standard scenarios performed to GLP standards for registration purposes including:

  • Effect of rainfall on volatilisation of pesticides from a soil surface
  • Air concentrations arising from transpiration of pesticides
  • Domestic losses of biocides to the environment
  • Veterinary medicinal product losses from farmyard
  • Uptake of pharmaceuticals into plants

Case study: Fate of Nanopesticides in soil

Soil sorption, degradation and column leaching experiments were performed to investigate the fate and behaviour of different nanoformulations of pesticides in soils.

  • Nanoformulations of pesticides can influence the environmental fate of the active ingredient
  • Preliminary results indicated greater sorption of the nanoformulations compared to the active ingredient
  • No consistent differences in degradation and leaching behaviour between nanoformulations and active ingredients
  • Current fate models are adequate for some nanoformulations, but alternatives may be needed for others

Contact Us - Chemicals

T: +44 (0)300 100 0324

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Chemical Brochure

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  • Forefront of regulatory exposure modelling
  • Unparalleled experience in environmental modelling & risk assessment
  • Close working relationships with EU Member State Competent Authorities, EFSA, DWI & CRD