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We have state of the art analytical capability to perform the studies below using radiolabelled or non-radiolabelled test items, giving our customers more flexibility to their ERA approach.
As more parent associated metabolite fate studies are required, Fera offer a range of bespoke studies which meet regulatory requirements. We can tailor the design of the standard OECD studies to meet specific customer requirements. We amend the test matrix, design and analysis to suit the analyte in question giving our customers more options to their risk assessment.
Fera's expert team supports its customers during the entire regulatory process, from questions about compound formulation to regulator queries regarding submitted risk assessments.
Current OECD Fate and Behaviour studies within Veterinary Medicines performed at Fera
OECD 106 / 121 - Adsorption/Desorption Using a Batch Equilibrium Method
OECD 307 - Aerobic and Anaerobic Transformation in Soil
OECD 308 - Aerobic and Anaerobic Transformation in Aquatic Sediment Systems
OECD 309 – Aerobic Mineralisation in Surface Water - Simulation Biodegradation Test
OECD 316 - Phototransformation of Chemicals in Water- Direct Photolysis
EMA/CVMP 2011 - Fate of Veterinary Medicinal products in Manure / Slurry
Our laboratories are equipped with state-of-the-art facilities that enable cost-effective performance of GLP compliant contract research environmental fate studies for pesticides, veterinary medicines, pharmaceuticals and industrial chemicals to satisfy regulatory requirements including:
Laboratory (GLP) analytical services for agrochemicals, REACH, veterinary medicinal products
Laboratory studies with radio-labelled and non-radiolabelled chemicals
Batch sorption including aged sorption and column leaching studies according to OECD guidelines and parameter estimation
Soil, water-sediment and manure/slurry biodegradation studies including estimation of degradation parameters and endpoints
Hard (man-made) surfaces fate studies including lab-scale sorption, wash-off, and field monitoring studies
Design, interpretation and analysis of lysimeter, field leaching, field dissipation and environmental (e.g. groundwater) monitoring studies
CCSS scientists have also undertaken bespoke studies investigating the fate of chemicals under non-standard scenarios performed to GLP standards for registration purposes including:
Effect of rainfall on volatilisation of pesticides from a soil surface
Air concentrations arising from transpiration of pesticides
Domestic losses of biocides to the environment
Veterinary medicinal product losses from farmyard
Uptake of pharmaceuticals into plants
Case study: Fate of Nanopesticides in soil
Soil sorption, degradation and column leaching experiments were performed to investigate the fate and behaviour of different nanoformulations of pesticides in soils.
Nanoformulations of pesticides can influence the environmental fate of the active ingredient
Preliminary results indicated greater sorption of the nanoformulations compared to the active ingredient
No consistent differences in degradation and leaching behaviour between nanoformulations and active ingredients
Current fate models are adequate for some nanoformulations, but alternatives may be needed for others