We have state of the art analytical capability to perform the studies below using radiolabelled or non-radiolabelled test items, giving our customers more flexibility to their ERA approach.
As more parent associated metabolite fate studies are required, Fera offer a range of bespoke studies which meet regulatory requirements. We can tailor the design of the standard OECD studies to meet specific customer requirements. We amend the test matrix, design and analysis to suit the analyte in question giving our customers more options to their risk assessment.
Fera's expert team supports its customers during the entire regulatory process, from questions about compound formulation to regulator queries regarding submitted risk assessments.
EFSA 2014 / NAFTA 2006 – Field dissipation studies for actives and transformation products.Additional Studies such as Time dependant (Aged) sorption and Plant Uptake factor assessments
Compound specific Plant Uptake Factor assessment
Chemicals at Fera are now able to commercially offer compound specific Plant Uptake Factor assessment studies for PPP's under GLP. Plant uptake studies have been designed to answer a specific question, what is the uptake of compounds from water by plant roots systems?
Plants are known to absorb dissolved compounds from soil pore water via their root system during regular water consumption. This standard process is implemented in regulatory accepted leaching models such as PEARL, PELMO or PRZM as a sink term influencing the mass balance of a compound in soil leading to the leaching potential in groundwater. Current guidance recommends a default value of '0' is applied to the models.
Plant uptake leads to a decrease of compound mass in the soil system and thus diminishes the amount of substance available for leaching. Leaching models simulate plant uptake by considering the soil water consumed by plants, the concentration of a substance freely available in the soil water (which is the result of sorption and degradation processes considered separately in the models) and the parameter "plant uptake factor" (PUF) sometimes attributed as Transpiration Stream Concentration Factor (TSCF).
Correct implementation of the plant uptake process in the FOCUS leaching models is an important factor in the regulatory assessment of many substances.
Chemicals are now able to offer a laboratory based assessment under GLP to accurately measure plant uptake. Chemicals use a hydroponics system which submerges the root system of the plant species into the treated solution and measures concentration over a set period.
Our laboratories are equipped with state-of-the-art facilities that enable cost-effective performance of GLP compliant contract research environmental fate studies for pesticides, veterinary medicines, pharmaceuticals and industrial chemicals to satisfy regulatory requirements including:
Our Chemicals scientists have also undertaken bespoke studies investigating the fate of chemicals under non-standard scenarios performed to GLP standards for registration purposes including:
Case study: Fate of Nanopesticides in soil
Soil sorption, degradation and column leaching experiments were performed to investigate the fate and behaviour of different nanoformulations of pesticides in soils.
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